Role of the Synthase Domain of Ags1p in Cell Wall -Glucan Biosynthesis in Fission Yeast
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منابع مشابه
Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast.
The cell wall protects fungi against lysis and determines their cell shape. Alpha-glucan is a major carbohydrate component of the fungal cell wall, but its function is unknown and its synthase has remained elusive. Here, we describe a fission yeast gene, ags1(+), which encodes a putative alpha-glucan synthase. In contrast to the structure of other carbohydrate polymer synthases, the predicted A...
متن کاملEvidence for the Essential Involvement of the Transglycosylase Domain of Ags1p in Cell Wall -Glucan Biosynthesis in Fission Yeast
Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of ...
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beta-Glucans are the main components of the fungal cell wall. Fission yeast possesses a family of beta-glucan synthase-related genes. We describe here the cloning and characterization of bgs3(+), a new member of this family. bgs3(+) was cloned as a suppressor of a mutant hypersensitive to Echinocandin and Calcofluor White, drugs that interfere with cell wall biosynthesis. Disruption of the gene...
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Glucan synthases synthesize glucans, complex polysaccharides that are the major components in fungal cell walls and division septa. Studying regulation of glucan synthases is important as they are essential for fungal cell survival and thus popular targets for anti-fungal drugs. Linear 1,3-β-glucan is the main component of primary septum and is synthesized by the conserved β-glucan synthase Bgs...
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The fungal cell wall is the essential cellular boundary, controlling many transport processes, cellular metabolism and, indeed, all communications with the extracellular world. Because of its mechanical strength, it allows cells to withstand turgor pressure and consequently prevents cell lysis. In the fission yeast Schizosaccharomyces pombe, the cell wall mainly consists of three polysaccharide...
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